YubaNet.com
Sunday, November 23 2014

            We Deliver News to the Sierra
News Fire News spacer Latest News spacer Regional News spacer California News spacer USA News spacer World News spacer Op-Ed spacer Enviro News spacer Sci Tech News spacer Life spacer Odd News spacer Cartoons spacer
Features The Calendar features features Weather features Sierra NightSky features features features Road Conditions features Home spacer
Sci/Tech
 

Violence puts wear and tear on kids' DNA


    Google+    

By: Duke University

DURHAM, N.C. April 24, 2012 - Children who have experienced violence might really be older than their years. The DNA of 10-year-olds who experienced violence in their young lives has been found to show wear and tear normally associated with aging, a Duke University study has found.

"This is the first time it has been shown that our telomeres can shorten at a faster rate even at a really young age, while kids are still experiencing stress," said Idan Shalev, a post-doctoral researcher in psychology and neuroscience at the Duke Institute for Genome Sciences & Policy.

Telomeres are special DNA sequences found at the tips of chromosomes; much like the plastic tips of shoelaces, they prevent DNA from unraveling. Emerging evidence suggests that telomeres are "master integrators," connecting stress to biological age and associated diseases.

Telomeres are known to get shorter each time cells divide, putting a limit on the number of times a given cell can go on dividing. Smoking, obesity, psychological disorders and stress have been found to possibly accelerate that process of telomere loss. In that sense, our telomeres may reflect biological age, not just chronological age.

Previous studies of telomeres and stress had primarily looked at telomeres in adults as they recalled experiences much earlier in their lives.

In the new study, Shalev took advantage of the Environmental-Risk Longitudinal Twin Study led by Duke's Avshalom Caspi and Terrie Moffitt that has followed 1,100 British families with twins since the time those twins were born in the 1990s. The twins are now 18-year-old adults, but the researchers performed the analysis on DNA samples collected when they were just five and 10 years old. The researchers also know, based on extensive interviews held with the twins' mothers, which of them experienced some form of violence in their younger years, including domestic violence, frequent bullying or physical maltreatment by an adult.

The new report in the journal Molecular Psychiatry shows that a subset of those children with a history of two or more kinds of violent exposures have significantly more telomere loss than other children. Since shorter telomeres have been linked to poorer survival and chronic disease, this may not bode well for those kids.

"Research on human stress genomics keeps throwing up amazing new facts about how stress can influence the human genome and shape our lives," said Caspi, the Edward M. Arnett Professor of Psychology and Neuroscience.

The findings suggest a mechanism linking cumulative childhood stress to telomere maintenance and accelerated aging, even at a young age. It appears to be an important way that childhood stress may get "under the skin" at the fundamental level of our cells.

"An ounce of prevention is worth a pound of cure," said Moffitt, who is the Knut Schmidt Nielsen Professor of Psychology and Neuroscience. "Some of the billions of dollars spent on diseases of aging such as diabetes, heart disease and dementia might be better invested in protecting children from harm."

The Duke team plans to further explore the new findings by measuring the average length of telomeres in the twins now that they are adults. They'll also repeat the study in a second, older group of 1,000 individuals in the Dunedin Study, who have been under observation since their birth in the 1970s in New Zealand.

CITATION: "Exposure to Violence During Childhood is Associated with Telomere Erosion from 5 to 10 Years of Age: A Longitudinal Study," Idan Shalev, Terrie Moffitt et al. Molecular Psychiatry, April 24th. doi:10.1038/mp.2012.32

 

Help us bring you more news. Be a real reader: Support YubaNet

By submitting a comment you consent to our rules. You must use your real first and last name, not a nickname or alias. A comment here is just like a letter to the editor or a post on Facebook. Thank you.

 

Latest Headlines

Sci/Tech

January-October temperatures break records

Samantha set for space station

Deep-Earth Carbon Offers Clues About Origin of Life on Earth

Business culture in banking industry favors dishonest behavior

Upstate New York Walloped by Lake Effect Snow (Satellite Photos)

Tornados of Fire: Examining the Fire Whirl Phenomenon

Spooky alignment of quasars across billions of light-years

New, Free Certificate Authority to Dramatically Increase Encrypted Internet Traffic

Hiding in plain sight: elusive dark matter may be detected with GPS satellites

Chemical in coffee may help prevent obesity-related disease


More

 

 

 

 

NEWS . Fire News . Latest . Regional . California . USA . World . Op-Ed . Enviro . Sci/Tech . Life . Odd News . Cartoons
FEATURES . The Calendar .Weather . Sierra NightSky. Road Conditions
YubaNet.com . Advertising. About Us . Support YubaNet . Contact Us . Terms of Use . Privacy

YubaNet.com © 1999-2014
Nevada City, California (530) 478-9600